心外膜射频消融治疗心房颤动的实验研究

目的 :探讨电学隔离肺静脉治疗心房颤动 (AF)的可行性和连续透壁径线的重要性。方法 :实验分为完全阻断组和未完全阻断组 ,每组犬各 7只。建立AF模型后 ,围绕肺静脉在心外膜进行射频消融。结果 :完全阻断组消融后AF持续时间与消融前比较差异有极显著性意义 (15 2 .7svs4 2 6 .3s ,P <0 .0 1) ;完全阻断组消融后在持续时间与未完全阻断组消融后比较差异也有极显著性意义 (15 2 .7svs 36 7.3s ,P <0 .0 1) ,而窦房结功能和房室传导功能无显著性变化。结论 :电学隔离肺静脉治疗AF是可行的 ,形成确切的连续透壁肺静脉损伤可简化消融治疗AF的径线。

Epicardial Application of Atrial Radiofrequency Ablation for Atrial Fibrillation in Canine Model

Objective: To investigate the feasibility of electrical isolation of pulmonary veins (PVs) with radiofrequency ablation in the treatment of atrial fibrillation (AF) and the importance of continuous transmural linear lesion. Methods: 14 dogs with experimental AF was divided into complete isolation group and incomplete isolation group. Epicardial circumferential radiofrequency ablation around PVs were performed after AF models were established. Results: Duration of AF was significantlly reduced after ablation than before operation in complete isolation group(152.7s vs 426.3s, P <0.01). AF duration were significantly shorten after ablation compared to that of the incomplete isolation group(152.7s vs 367.3s, P <0.01) . There were no significant change in sinoatrial node and atrioventricular conduction function. Conclusion: Pulmonary veins isolation is an feasible treatment for AF. Ablation linear for the treatment of AF can be simplified if continuous and transmural lesion were produced.