甘草对抗D-半乳糖诱导大鼠糖尿病模型的实验研究

目的探讨甘草、二甲双胍和水飞蓟宾对D-半乳糖诱导大鼠糖尿病模型的作用。方法以腹腔注射D-半乳糖（150mg／kg，1次／d，共8周）诱导胰岛素抵抗（IR），选用长期腹腔注射5％D-半乳糖150mg／（kg·d）]诱导IR形成大鼠糖尿病模型，并测定空腹血糖（FBG）、糖耐量试验（OGTT）后2h血糖（2hBG）含量和体重变化。结果空白对照组、甘草组、二甲双胍组和水飞蓟宾组与模型组比较，FBG均无明显差异（P〉0．05）；而OGTT后2hBG，模型组与空白对照组比较存在明显差异（P〈0．01）；甘草、二甲双胍和水飞蓟宾均使造模后各组的大鼠体重增加，并能降低糖尿病大鼠的血糖水平。结论甘草、二甲双胍和水飞蓟宾能有效地抑制D-半乳糖所致糖尿病大鼠的血糖水平。

Effects of Glycyrrhiza on Rats with Diabetes Mellitus Induced by D-Galactose

Objective To study the effects of glycyrrhiza,metformin (MET) and silibinin (SIL) on rats with diabetes mellitus induced by D-galactose (D-gal).Methods The animal models of diabetes mellitus with insulin resistance (IR) were prepared by administered (i.p.) D-gal (150 mg/kg qd) for 56 d.Fasting blood glucose (FBG) and 2 h blood glucose (2 h BG) after oral glucose tolerance test (OGTT) were measured,as well as the body weight.Results There was no significant difference of FBG among the control group,glycyrrhiza group,MET group and SIL group (P > 0.05).Otherwise there was significant difference between the control group and negative group in 2 h BG (P < 0.01). Compared with the negative group,D-gal significantly increased the level of weight and decreased the level of blood sugar in rats with diabetes mellitus.Conclusion Glycyrrhiza,MET and SIL can antagonize D-gal-induced diabetes mellitus in rats.