Acid-base properties of pristinamycin IA and related compounds. |
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| Authors: | M Largeron M B Fleury |
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| Affiliation: | Laboratoire de Chimie Analytique et Electrochimie, Centre National de la Recherche Scientifique, 1310, Faculte de Pharmacie, Paris, France. |
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| Abstract: | The pKa values of acid-base equilibria involved in the protonation of pristinamycin IA and its model compound, N-isobutyl-3-hydroxypicolinamide, were determined by UV-visible absorption spectrometry and potentiometric titration. The equilibrium between dipolar ionic and uncharged neutral forms was investigated spectrometrically in methanol-water solutions. With pristinamycin IA, the dipolar ionic form predominated in aqueous solutions buffered to the isoelectric pH. The effects of structure on the ionization constants are briefly discussed. |
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