| PBNA-413对离体心脏缺血再灌注损伤时抗氧化作用的影响 |
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| 引用本文： | 黄志华,李良东,黎晓,肖海,曾靖.PBNA-413对离体心脏缺血再灌注损伤时抗氧化作用的影响[J].时珍国医国药,2010,21(2). |
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| 作者姓名： | 黄志华 李良东 黎晓 肖海 曾靖 |
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| 作者单位： | 赣南医学院,江西,赣州,341000 |
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| 基金项目： | 江西省教育厅科技项目课题 |
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| 摘 要： | 目的 研究拳参正丁醇提取物(PBNA)的水溶性成分PBNA-413对离体心脏缺血再灌注损伤时的抗氧化作用.方法 应用大鼠离体心肌缺血再灌注损伤模型,在灌流液中加入高、中、低剂量的拳参正丁醇提取液进行再灌注.再灌注结束后,测定心肌组织乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-Px)的活性及丙二醛(MDA)的含量.结果 各剂量的PBNA-413治疗后,均能提高心肌组织LDH(P<0.01)、SOD(P<0.05)、GSH-Px(P<0.01)的活性,升高NO(P<0.05)含量,降低MDA(P<0.001)及LD(P<0.01)的含量,且呈明显的剂量依赖性.结论 拳参正丁醇提取物可通过提高抗氧化酶系统的功能、减少心肌酶的释放而保护缺血再灌注心肌.
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| 关 键 词： | 缺血再灌注损伤 抗氧化 |
The Anti-oxidative Effects of PBNA-413 on Isolated Myocardial Ischemia/Reperfusion Injury |
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| HUANG Zhi-hua,LI Liang-dong,LI Xiao,XIAO Hai,ZENG Jing.The Anti-oxidative Effects of PBNA-413 on Isolated Myocardial Ischemia/Reperfusion Injury[J].Lishizhen Medicine and Materia Medica Research,2010,21(2). |
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| Authors: | HUANG Zhi-hua LI Liang-dong LI Xiao XIAO Hai ZENG Jing |
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| Institution: | HUANG Zhi-hua,LI Liang-dong,LI Xiao,XIAO Hai,ZENG Jing(Gannan Medical College,Ganzhou,341000,China) |
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| Abstract: | Objective To explore the anti-oxidative effects of water-soluble constituent of polygonum bistorta L.n-butyl alcohol(PBNA-413) in isolated myocardial ischemia/reperfusion injury.Methods A rat myocardial ischemia/reperfusion injury was made and treated with PBNA-413(high dose,medium dose and low dose).The content of malondialdehyde(MDA) and the activities of lactate dehydrogenase(LDH),superoxide dismutase(SOD) and glutathion peroxidase GSH-Px) were investigated.Results PBNA-413 coud significantly increase th... |
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| Keywords: | PBNA-413 PBNA-413 Myocardial ischemia/reperfusion injury Anti-oxidation |
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