Does high MHC class II gene expression in normal lungs account for the strong immunogenicity of lung allografts? |
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Authors: | Ian P. J. Alwayn Renkui Xu William H. Adler Dilip S. Kittur |
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Affiliation: | (1) Leiden University Medical School, Rijnsburgerweg 10, NL-2333 AA Leiden, The Netherlands;(2) Division of Transplant Surgery, The Johns Hopkins Medical Institutions, Harvey 805, 600 N. Wolfe Street, 21287 Baltimore, MD, USA;(3) Gerontology Research Center, NIA, 21287 Baltimore, MD, USA |
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Abstract: | Clinical experience has demonstrated that lung allografts are considerably more immunogenic than liver allografts although both organs contain equivalent amounts of lymphoreticular tissue. Northern blot analysis of MHC class II gene expression in various murine organs with I-AB and I-EB gene-specific oligonucleotide probes revealed that MHC class II expression in lungs is semiquantitatively higher than in the liver and other organs with the exception of the spleen. We conclude that this high MHC class II expression strongly suggests that the lymphoreticular tissue in the lungs is in a state of activation. This may be an important reason for the strong immunogenicity of lung allografts. |
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Keywords: | Lung transplantation, mice MHC class II expression, lung Rejection, lung, mice |
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