| 共刺激分子4-1BB与类风湿性关节炎 |
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| 引用本文： | 闵月,李晓忠. 共刺激分子4-1BB与类风湿性关节炎[J]. 国际免疫学杂志, 2009, 32(3): 230-234. DOI: 10.3760/cma.j.issn.1673-4394.2009.03.018 |
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| 作者姓名： | 闵月 李晓忠 |
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| 作者单位： | 苏州大学附属儿童医院肾脏免疫科,215003;苏州大学附属儿童医院肾脏免疫科 |
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| 基金项目： | 国家自然科学基金，江苏省卫生厅课题 |
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| 摘 要： | 共刺激分子4-1BB及其配体4-1BBL属于肿瘤坏死因子超家族成员，为、T细胞的活化、增殖提供第二信号，并可促进细胞因子的分泌。类风湿性关节炎（RA）是一种慢性系统性自身免疫性疾病，已证实T细胞功能的偏移及细胞因子表达异常在RA的免疫炎症损伤的发生发展过程中起着重要作用，而4-1BB作为RA发病机制中的关键性因素已成为目前研究的热点，通过干预4-1BB／4—1BBL信号途径对RA进行免疫治疗也已是当前的研究方向。
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| 关 键 词： | 4-1BB 类风湿性关节炎 |
The costimulatory molecule 4-1BB and rheumatoid arthritis |
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| MIN Yue. The costimulatory molecule 4-1BB and rheumatoid arthritis[J]. International Journal of Immunology, 2009, 32(3): 230-234. DOI: 10.3760/cma.j.issn.1673-4394.2009.03.018 |
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| Authors: | MIN Yue |
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| Affiliation: | MIN Yue. (Soochow University Affiliated Children＇ s Hospital, Soochow 215003, China) |
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| Abstract: | Costimulator molecules 4-1BB and its ligand 4-1BBL belong to the TNF super family.They pro-vide the second signal for the activation and proliferation of T lymphocytes and increase some cytokine.pro-duction.It was discovered that disturburance of T cells and the related cytokine secretion participated in the immunopathologic process of rheumatic arthritis(RA),a common chronic systemic autoimmune disease.4-1BB/4-1BBL'S dual immunoregulative effects were currently studied in many research papers.Thus the immune intemvention of the 4-1BB/4-1BBL signal is becoming a theraputic approach for various kinds of diseases.In this paper,we discuss about their biologic and constructive effects on the pathogeneis,diagnosis and treatment of RA. |
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| Keywords: | 4-1BB |
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