| 白藜芦醇衍生物RT-B与大鼠血浆蛋白结合率的测定 |
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| 引用本文： | 刘杨,林建阳,陈晓辉,韩晶,毕开顺. 白藜芦醇衍生物RT-B与大鼠血浆蛋白结合率的测定[J]. 中国新药与临床杂志, 2008, 27(6) |
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| 作者姓名： | 刘杨 林建阳 陈晓辉 韩晶 毕开顺 |
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| 摘 要： | 目的建立测定白藜芦醇衍生物RT—B与大鼠血浆蛋白结合率的方法。方法采用平衡透析法对RT-B与大鼠血浆蛋白结合率进行HPLC测定。结果低、中、高3种浓度下,RT-B的血浆蛋白结合率分别为(79.2±s 0.7)%,(80.1±0.9)%和(80.2±0.9)%。结论本方法灵敏度高,重现性好,操作简单,能满足分析要求。RT-B与大鼠血浆蛋白的结合率较高。
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| 关 键 词： | 血浆 蛋白质结合 色谱法，高压液相 平衡透析法 白藜芦醇衍生物 |
Determination of rat plasma protein binding rate of resveratrol derivative RT-B |
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| LIU Yang,LIN Jian-yang,CHEN Xiao-hui,HAN Jing,BI Kai-shun. Determination of rat plasma protein binding rate of resveratrol derivative RT-B[J]. Chinese Journal of New Drugs and Clinical Remedies, 2008, 27(6) |
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| Authors: | LIU Yang LIN Jian-yang CHEN Xiao-hui HAN Jing BI Kai-shun |
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| Abstract: | AIM To develop a method for the determination of the plasma protein binding rate of RT-B. METHODS The equilibrium dialysis was carried out to determine the plasma protein binding rate of RT-B. RESULTS The plasma protein binding rates of RT-B at low,middle and high concentrations were (79.2±s 0.7)%,(80.1±0.9)% and (80.2±0.9)%,respectively.CONCLUSION This method shows the high binding power of RT-B to rat plasma protein with high sensitivity,good reproduction,simple management and fulfilling the requirement of analysis. |
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| Keywords: | plasma protein binding chromatography,high pressure liquid equilibrium dialysis resveratrol derivative |
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