慢性阻塞性肺疾病合并肺间质纤维化临床分析

目的了解慢性阻塞性肺疾病合并肺间质纤维化的临床特点。探讨其临床意义。方法对比分析该院1995－2005年诊断的慢性阻塞性肺疾病（COPD）合并肺间质纤维化25例及特发性肺纤维化（IPF）26例患者的病程、症状、体征及x线、胸片、胸部高分辨CT（HRCT）、肺功能及血气分析结果。结果COPD合并肺间质纤维化呼吸困难进展较快，具有两种病变并存的x线及HRCT表现，常为混合型通气功能障碍，低氧血症明显，二氧化碳潴留则有所减轻。结论慢性阻塞性肺疾病并肺间质纤维化具有独特的临床特点，兼有二者的特征。

Clinical analysis of chronic obstructive pulmonary disease with pulmonary interstitial fiberosis

Objective] To explore the clinical characteristics of chronic obstructive pulmonary diseases (COPD) with pulmonary interstitial fibrosis. Methods] 25 COPD patients following with pulmonary interstitial fibrosis and 26 patients with idiopathic pulmonary fibrosis (IPF) were retrospectively compared. Clinical symptoms, chest radiography features, high resolution computed tomography (HRCT) of the chest, lung function and arterial blood gas were analyzed. Results] COPD with pulmonary interstitial fibrosis had more progressive dyspnea, mixed dysfunction, hypoxemia and radiographic signs of the two diseases, but less CO2 retention. Conclusion] COPD and IPF are different diseases. When they coexist in some patients, their clinical manifestations have characteristics of both diseases.