奥氮平与碳酸锂治疗躁狂发作30例对照分析

目的评价奥氮平治疗躁狂症的疗效与耐受性。方法将符合《中国精神障碍分类与诊断标准（第3版）》（CCMD-3）中各型躁狂发作诊断标准的60例住院患者随机分为两组,每组30例,分别用奥氮平和碳酸锂治疗6周。以Bech—Rafaelsen躁狂量表（BRMS）评定疗效,以副反应量表（TESS）及相关辅助检查评价耐受性。结果治疗前后两组BRMS分值均有非常显著性差异,治疗有效率相当;组间比较显示,奥氮平治疗后第1周BRMS评分即显著下降,表明奥氮平较碳酸锂起效迅速。两组的不良反应均少且轻。结论奥氮平可作为心境稳定剂用于躁狂发作的治疗。

Comparative Analysis on Olanzapine and Lithium Carbonate in the Treatment for Manic Episodes of 30 Cases

Objective To evaluate the efficacy and tolerability of olanzapine in the treatment for manic episodes. Methods Based on classification and diagnostic criteria for mental discoders version 3 （CCMD-3）, our research set the treatment group and control group fol- lowing below process： 60 patients with various types of diagnostic criteria for manic episodes were randomly divided into two groups （n=30）. Treatment group was treated with olanzapine and control group used lithium carbonate for 6 weeks. The efficacy was assessed by Bech-Rafaelsen Mania Scale （BRMS）, the tolerability was evaluated by Emergent Symptom Scale （TESS） and examining other related effects. Results The BRMS scores of control group and treatment group had significant difference after treatment. However, treatment effects of both groups had similar performance. The comparison of the two groups showed that the BRMS of treatment group decreased significantly which meant the olanzapine talced effects more rapidly than lithium carbonate. In the two groups adverse reactions were low and light. Conclusion Olanzapine can be used as a mood stabilizer to treat the manic episodes.