| DNA甲基化与胆囊癌 |
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| 引用本文： | WU Chun-Li,耿小平,ZHU Li-Xin. DNA甲基化与胆囊癌[J]. 国际外科学杂志, 2008, 35(8): 568-571 |
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| 作者姓名： | WU Chun-Li 耿小平 ZHU Li-Xin |
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| 作者单位： | Department of Hepatobiliary Surgery, First Affiliated Hospital of Anhui Medical University,Anhui 230022, China;安徽医科大学第一附属医院肝胆外科,安徽,230022 |
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| 摘 要： | DNA甲基化是真核生物的正常修饰方式,异常的DNA甲基化与肿瘤的发生发展密切相关,具有重要生物学意义.胆囊癌中肿瘤相关基因启动子的异常甲基化,作为表观遗传标记物,在胆囊癌的发病、诊治、疗效观察及预后判断等方面可能发挥重要作用.
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| 关 键 词： | DNA甲基化 胆囊癌 基因 肿瘤 |
DNA methylation and gallbladder carcinoma |
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| WU Chun-Li,GENG Xiao-Ping,ZHU Li-Xin. DNA methylation and gallbladder carcinoma[J]. International Journal of Surgery, 2008, 35(8): 568-571 |
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| Authors: | WU Chun-Li GENG Xiao-Ping ZHU Li-Xin |
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| Abstract: | DNA methylation is a normal modification mode of eukaryon, there is an intimate relationship between aberrant promoter methylation of tumor-related genes and the generation or development of neo- plasms,emerging significantly biological effectiveness. Aberrant promoter methylation of tumor-related genes as the epigenetic markers, maybe play a very important role in the incidence, diagnosis, therapeutic effects, prognosis judgements and other aspects in gallbladder carcinoma. |
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| Keywords: | DNA methylation gallbladder carcinoma genes neoplasms |
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