| 环匹阿尼酸对一氧化氮、硝普纳和8－溴鸟苷环一磷酸松弛家兔主动脉作用的影响 |
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| 引用本文： | 罗大力,杨宝峰,李光泽. 环匹阿尼酸对一氧化氮、硝普纳和8－溴鸟苷环一磷酸松弛家兔主动脉作用的影响[J]. 中国药理学与毒理学杂志, 1995, 0(4) |
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| 作者姓名： | 罗大力 杨宝峰 李光泽 |
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| 作者单位： | 哈尔滨医科大学药理教研室 |
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| 摘 要： | 环匹阿尼酸对一氧化氮、硝普纳和８－溴鸟苷环一磷酸松弛家兔主动脉作用的影响罗大力，杨宝峰，李光泽（哈尔滨医科大学药理教研室，哈尔滨１５００８６）硝酸酯类血管扩张剂对心绞痛和顽固性心衰等疾病的治疗发挥十分重要的作用。其松弛血管平滑肌的机理与内源性血管平滑...
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| 关 键 词： | 环匹阿尼酸，一氧化氮，主动脉，胸，鸟苷环一磷酸 |
Effect of cyclopiazonic acid on aortic relaxation induced byNO,nitroprusside sodium and 8-bromo-cGMP in rabbits |
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| Luo Da-Li,Yang Bao-Feng,LI Guang-Ze. Effect of cyclopiazonic acid on aortic relaxation induced byNO,nitroprusside sodium and 8-bromo-cGMP in rabbits[J]. Chinese Journal of Pharmacology and Toxicology, 1995, 0(4) |
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| Authors: | Luo Da-Li Yang Bao-Feng LI Guang-Ze |
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| Affiliation: | Luo Da-Li,Yang Bao-Feng,LI Guang-ZeDepartment of Pharmacology,Harbin Medical University,Harbin 150086) |
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| Abstract: | The mechanism of arterial relaxationinduced by cyclic GMP-generators was studied inrabbit aortic rings by using cyclopiazonic acid (CPA),aselective inhibitor of sarcoplasmic reticulum(SR)Ca2+-pump.CPA 30 μmol·L-1 inhibited therelaxing effects of nitric oxide(NO).nitroprussidesodium(NPS)and 8-bromo-cGMP on the aorticrings contracted by 1 μmol·L-1 phenylephrine,andthe percentages of the maximal inhibition by CPA inthe above three groups were 45%,43% and 23%respectively.In conclusion,the result further indicatedthat the enhanced activity of SR Ca2+-pump might beone of the important mechanisms for the aortic relaxa-tion induced by cGMP-generators in rabbits. |
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| Keywords: | cyclopiazonic acid nitric oxide aorta thoracic guanosine cyclic monophosphate |
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