| 氟对大鼠肝细胞影响及SOD阻断因子的透射电镜研究 |
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| 引用本文： | 边晓燕 王志成. 氟对大鼠肝细胞影响及SOD阻断因子的透射电镜研究[J]. 中国地方病学杂志, 1993, 12(3): 136-137,F003 |
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| 作者姓名： | 边晓燕 王志成 |
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| 作者单位： | 哈尔滨医科大学电镜室(边晓燕，吴振铎，李红，张亚坤)，哈尔滨医科大学附属二院(王志成，吴莹，关德宏，闫景龙)，中国地方病防治研究中心氟病所(石玉霞)，中国地方病防治研究中心氟病所(富德) |
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| 摘 要： | 本实验分正常组、投氟组、投氟加超氧化物歧化酶(SOD)组喂养大鼠六个月后处死,制作肝组织的透射电子显微镜标本,进行超微结构观察。结果发现,投氟组肝细胞产生明显的毒性作用,表现为肝细胞肿胀,细胞膜破损,线粒体变性,核形不整、固缩,一些肝细胞崩解。在投氟加 SOD 的两种喂养方法中,一组肝细胞出现一些可逆性损伤,而另一组肝细胞结构与正常组近似。提示 SOD 作为抗氧化剂对食入大剂量氟的大鼠肝细胞有保护作用。
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| 关 键 词： | 氟 肝细胞 超微结构 超氧物歧化酶 |
Effect of fluorine and superoxidase on the rat hepatocyte ultrastructure |
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| Bian Xiaoyan,et al.. Effect of fluorine and superoxidase on the rat hepatocyte ultrastructure[J]. Chinese Jouranl of Endemiology, 1993, 12(3): 136-137,F003 |
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| Authors: | Bian Xiaoyan et al. |
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| Affiliation: | Bian Xiaoyan,et al.Harbin Medical university |
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| Abstract: | This experiment was divided into con-trasted group,fluorinated (F) group and fluo-rinated together with superoxidase (SOD)group.After feeding the rats for six monthes,they were put to death and took the liver tis-sue for TEM specimen.the resaults of ultra-structural observation showed that the hepato-cytes injury,cellular edema mitochondrialswelling necrosis and so on,were evident inthe fluorinated group.In the other two groupsof F+SOD,one group appeared some re-versible injury and another was similar to con-trasted group,which indicated SOD could pro-tect rat liver from the injury b(?) the fluorine. |
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| Keywords: | fluorine SOD rat hepatocyte ultrastructure |
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