冠心病患者炎症标志物检测的临床意义

目的:检测冠心病患者炎症标志物浓度,并探讨其在冠心病冠状动脉粥样硬化(As)中的作用。方法:用酶联免疫吸附试验检测冠心病患者血清中肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的浓度,用散射免疫比浊法检测冠心病患者血清中C反应蛋白(CRP)的浓度,并与正常对照组比较。结果:冠心病患者不稳定性心绞痛组和急性心肌梗死组TNF-αI、L-6和CRP浓度比正常对照组和冠心病患者稳定性心绞痛组显著升高(P<0.05或P<0.01);稳定性心绞痛组TNF-αI、L-6和CRP浓度比正常对照组高,但无显著差异(P>0.05)。结论:炎症标志物TNF-αI、L-6和CRP间相互作用,可能共同参与冠心病冠状动脉粥样硬化的发生发展过程,监测其浓度变化对冠心病有重要意义。

Clinical Significance of Inflammatory Markers in Patients with Coronary Heart Disease

Objective: To measure the concentration of inflammatory markers in patients with coronary heart disease(CHD) and explore its function in atherosclerosis(As)of coronary heart disease.Methods:The concentration of C-reactive protein(CRP) was measured with nephelometry,and the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) were determined with ELISA.Then the values of them were compared with that in normal controls.Results: The plasma CRP,TNF-α and IL-6 levels in patients with unstable angina pectoris and acute myocardial infarction were markedly higher than that in patients with stable angina pectoris and normal controls(P<0.05 or P<0.01),but the concentrations of inflammatory markers were similar in group of stable angina pectoris and normal controls(P>0.05).Conclusion: CRP,TNF-α and IL-6 interact,they may play an important role in occurrence and development of atherosclerosis in coronary heart disease.It is of great importance for coronary heart disease to monitor the concentration of inflammatory markers.