Tumor lysis syndrome and metastatic melanoma |
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Authors: | Marshall W Meeks Muhammad B Hammami Katherine J Robbins Kevin L Cheng Jack M Lionberger |
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Institution: | 1.Department of Medical Oncology,Saint Louis University School of Medicine,Saint Louis,USA;2.Department of Gastroenterology and Hepatology,Saint Louis University School of Medicine,Saint Louis,USA;3.Department of Pathology,Saint Louis University School of Medicine,Saint Louis,USA |
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Abstract: | Tumor lysis syndrome (TLS) is a potential emergent complication of oncologic treatment. TLS is commonly reported in hematological malignancies with rapid cell turnover rates, but is relatively rare in solid tumors. TLS is most frequently a result of cancer treatment in combination with a large tumor burden, but has occasionally been reported to occur spontaneously, especially in cases of advanced or metastatic disease. In this article, we describe the case of a patient with newly diagnosed metastatic melanoma that developed TLS two days after initiation of corticosteroids. In addition, we present a brief literature review of melanoma-associated TLS and review the etiology, diagnosis, and management of TLS. |
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