长期质子泵抑制剂治疗老年反流性食管炎11例

目的:研究老年反流性食管炎患者长期服用质子泵抑制剂的临床特点和不利因素,为防治老年反流性食管炎提供依据．方法:对11例长期服用质子泵抑制剂的老年人进行随访观察,分析其临床症状及内镜上消化道黏膜病变的发展变化,研究长期用药的影响．结果:11例患者在随访中,长期使用质子泵抑制剂均取得良好的症状控制,1例长期服用后出现十二指肠息肉,病理为绒毛状腺瘤．结论:老年反流性食管炎患者长期服用质子泵抑制剂的的疗效值得肯定,但需警惕对上消化道肿瘤发生的影响．

Long-term use of proton pump inhibitors in treatment of reflux esophagitis in 11 aged patients

AIM: To observe the changes of symptoms in the aged patients with reflux esophagitis (RE) after long-term use of proton pump inhibitors (PPI). METHODS: Eleven RE patients over 70 years old, who received PPI treatment for above 5 years, were investigated. The changes of reflux symptoms, the development of mucosal lesions under endoscope and the effects of PPI were analyzed. RESULTS: Reflux symptoms were well controlled in all the 11 patients. Polypi (villous adenoma pathologically) were founded in duodenum in one case, who had been continuously treated with PPI for 6 years. CONCLUSION: Long-term use of PPI is benefit for the aged RE patients in the control of the symptoms, but it is necessary to pay attention to the occurrence of digestive cancer.