| 乙醛脱氢酶2与硝酸酯耐药关系的研究进展 |
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| 引用本文： | 郝盼盼,陈玉国,张运. 乙醛脱氢酶2与硝酸酯耐药关系的研究进展[J]. 心血管病学进展, 2010, 31(1): 50-52. DOI: 10.3969/j.issn.1004-3934.2010.01.016 |
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| 作者姓名： | 郝盼盼 陈玉国 张运 |
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| 作者单位： | 山东大学教育部和卫生部心血管重构与功能研究重点实验室,山东大学齐鲁医院,山东,济南,250012 |
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| 摘 要： | 从19世纪后期开始,硝酸酯类药物就应用于稳定型心绞痛、急性心肌梗死及慢性充血性心力衰竭的临床治疗。然而,长期应用时机体血管很快对其产生耐药,影响了该类药物的血流动力学和抗缺血效果。其耐药机制极为复杂,尚不十分清楚。近来研究表明,线粒体内活性氧簇的产生和继发乙醛脱氢酶2的氧化失活,在硝酸酯耐药和交叉耐药产生过程中起重要作用。
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| 关 键 词： | 硝酸酯耐药 线粒体乙醛脱氢酶2 氧化应激 |
Progress in Research in Role of Mitochondrial Aldehyde Dehydrogenase in Nitrate Tolerance |
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| HAO Pan-pan,CHEN Yu-guo,ZHANG Yun. Progress in Research in Role of Mitochondrial Aldehyde Dehydrogenase in Nitrate Tolerance[J]. Advances in Cardiovascular Diseases, 2010, 31(1): 50-52. DOI: 10.3969/j.issn.1004-3934.2010.01.016 |
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| Authors: | HAO Pan-pan CHEN Yu-guo ZHANG Yun |
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| Affiliation: | HAO Pan-pan,CHEN Yu-guo,ZHANG Yun(Key Laboratory of Cardiovascular Remodeling , Function Research,Chinese Ministry of Education , Chinese Ministry of Public Health,Qilu Hospital of Sh,ong University,Jinan 250012,China) |
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| Abstract: | Organic nitrates are a group of very effective anti-ischemic drugs used for the treatment of patients with stable angina,acute myocardial infarction and chronic congestive heart failure. Long-term therapy with organic nitrates,however,results in a rapid development of nitrate tolerance,thus blunting their hemodynamic and anti-ischemic efficacy. Recent studies have revealed that mitochondrial reactive oxygen species formation and a subsequent oxidative inactivation of the mitochondrial aldehyde dehydrogenase... |
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| Keywords: | nitrate tolerance mitochondrial aldehyde dehydrogenase oxidative tress |
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