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| 芦荟对小鼠恶性腹水模型的影响 | |
| 引用本文： | 陈丽宏,路凡,沈新,陈葳,李旭,黄剑峰,杨春荣.芦荟对小鼠恶性腹水模型的影响[J].第四军医大学学报,2006,27(6):495-497. |
| 作者姓名： | 陈丽宏 路凡 沈新 陈葳 李旭 黄剑峰 杨春荣 |
| 作者单位： | 1. 陕西省人民医院妇产科,陕西,西安,710068 2. 第四军医大学基础部生物化学与分子生物学教研室,陕西,西安,710033 3. 西安交通大学第一医院分子生物学中心,陕西,西安,710061 |
| 摘 要： | 目的：探讨中药芦荟对小鼠恶性腹水模型的影响．方法：将S180细胞接种于Balb／c小鼠腹腔，制备小鼠恶性腹水模型；分别用芦荟全叶汁、凝胶汁、皮汁的不同剂量组灌胃治疗2wk，同时设阳、阴性对照；检测治疗前后小鼠的体质量、腹水蛋白质含量的变化，用流式细胞仪分析腹水中S180细胞的细胞周期变化．结果：芦荟全叶汁、凝胶汁、皮汁的高、低剂量组均可使模型小鼠体质量的快速增长减缓（P〈0．05）、腹水中自蛋白含量减少（P〈0．05）；S180细胞周期中：G1期细胞减少，S期细胞增多，与未治疗组比较有统计学差异（P〈0．05）．结论：芦荟对恶性腹水的治疗有良好的应用前景． |
| 关 键 词： | 芦荟 小鼠 近交BALB C 恶性腹水 细胞周期 |
| 文章编号： | 1000-2790(2006)06-0495-03 |
| 收稿时间： | 2005-09-14 |
| 修稿时间： | 2005-10-31 |
Effect of Aloe on rat models of malignant ascites |
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| CHEN Li-Hong,LU Fan,SHEN Xin,CHEN Wei,LI Xu,HUANG Jian-Feng,YANG Chun-Rong.Effect of Aloe on rat models of malignant ascites[J].Journal of the Fourth Military Medical University,2006,27(6):495-497. | |
| Authors: | CHEN Li-Hong LU Fan SHEN Xin CHEN Wei LI Xu HUANG Jian-Feng YANG Chun-Rong |
| Abstract: | AIM: To investigate the effect of Aloe, a kind of traditional Chinese drug, on the rat models of malignant ascites. METHODS: The malignant ascites model of Balb/c rat was induced by S_ 180 cells and then was treated with the different doses of whole leaf, gel and peel of Aloe for 2 weeks. The therapeutic effect was evaluated by comparing the change of rat body mass, protein content in ascite and changes of S_ 180 cell cycle in the rats. RESULTS: The Aloe delayed the rapid increase of the body mass in rat models(P<0.05)and decreased the albumin in ascites (P<0.05). The analysis of cell cycle displayed that the G1 phase cells were decreased and the S phase cells were increased in the Aloe treatment group compared with those in the blank group. CONCLUSION: Aloe showsa great potential in the treatment of malignant ascites. |
| Keywords: | Aloe mice inbred BALB C malignant ascites cell cycle |
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