Studies on azabicyclo systems: syntheses and spasmolytic activity of analogues of 9-methyl-3,9-diazabicyclo[4.2.1]nonane and 10-methyl-3,10-diazabicyclo[4.3.1]decane |
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| Authors: | Balkishen Razdan Ashok K Sharma Kanya Kumari Ramesh B Bodla Bharat L Gupta Gyanendra K Patnaik |
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| Institution: | 1. Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India;2. Department of Chemistry, Krishnasamy College of Engineering and Technology, Cuddalore, Tamil Nadu 607 109, India |
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| Abstract: | The spasmolytic activity of the lactams, 9-methyl-3,9-diazabicyclo4.2.1]nonan-4-one 1 and 10-methyl-3,10-diazabicyclo4.3.1]decan-4-one 2 and their reduction products, 9-methyl-3,9-diazabicyclo4.2.1]nonane 3 and 10-methyl-3,10-diazabicyclo4.3.1]decane 4 are described. Syntheses and spasmolytic effects of new amides and sulfonamides of the amines 3 and 4 are also reported. 3 possessed specific anti-serotonin activity. Amides of 3 with aromatic acids resulted in specific anti-histaminic compounds, whereas amides of 4 with aliphatic acids showed spasmogenic activity. A number of amides and sulfonamides showed non-specific spasmolytic activity. |
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| Keywords: | azabicyclo systems spasmolytic activity amides & sulfonamides of 9-methyl-3 9-diazabicyclo[4 2 1]nonane amides & sulfonamides of 10-methyl-3 10-diazabicyclo[4 3 1]decane spasmolytic activity of amides & sulfonamides structure— activity relationship in tropane & N-methylgranatane analogues |
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