| 婴幼儿人巨细胞病毒感染的临床表现和糖蛋白B基因分型 |
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| 引用本文： | 陆晓东,单小云,袁青,朱以军,郑雅萍,徐瑞龙.婴幼儿人巨细胞病毒感染的临床表现和糖蛋白B基因分型[J].中国妇幼保健,2011,26(18):2761-2763. |
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| 作者姓名： | 陆晓东 单小云 袁青 朱以军 郑雅萍 徐瑞龙 |
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| 作者单位： | 浙江省金华市中心医院检验科,321000 |
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| 摘 要： | 目的:了解婴幼儿人巨细胞病毒(HCMV)活动性感染的临床表现,以及与糖蛋白B(gB)基因型的关系。方法:ELISA法检测HCMV-IgM确定的HCMV阳性的婴幼儿51例,对其不同临床症状进行分析。对其中43例患儿使用套式PCR(nPCR)法加限制性长度多态性分析(RFLP)进行HCMV gB基因分型。结果:在51例HCMV感染患儿中全身性感染和单脏器感染分别占25.49%和74.51%,HCMV包涵体病和肝炎分别占25.49%和21.57%。43例患儿HCMV gB的基因分型结果为,gBI型20例,gB II型7例,gB III型9例,gB I、II混合型4例,gB I、III混合型2例,gB II、III混合型1例,未发现gB IV型。gB I型占46.51%。结论:婴幼儿HCMV感染临床表现种类多样;HCMV感染者以gB I型HCMV占多数。
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| 关 键 词： | 人巨细胞病毒 婴幼儿 糖蛋白B 临床表现 基因分型 |
Clinical manifestations of human cytomegalovirus infection of infants and genotype of glycoprotein B |
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| LU Xiao-Dong,SHAN Xiao-Yun,YUAN Qing et al.Clinical Laboratory,Jinhua Central Hospital,Jinhua ,Zhejiang,China.Clinical manifestations of human cytomegalovirus infection of infants and genotype of glycoprotein B[J].Maternal and Child Health Care of China,2011,26(18):2761-2763. |
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| Authors: | LU Xiao-Dong SHAN Xiao-Yun YUAN Qing Clinical Laboratory Jinhua Central Hospital Jinhua Zhejiang China |
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| Institution: | LU Xiao-Dong,SHAN Xiao-Yun,YUAN Qing et al.Clinical Laboratory,Jinhua Central Hospital,Jinhua 321000,Zhejiang,China |
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| Abstract: | Objective:To understand the clinical manifestations of human cytomegalovirus(HCMV) activate infection of infants and its relationship with genotype of glycoprotein B.Methods:ELISA method was used to detect 51 infants with positive HCMV diagnosed by HCMV-IgM,and the different clinical symptoms were analyzed.Genotyping of HCMV glycoprotein B was performed among 43 infants by nested PCR and restriction fragment length polymorphism(RFLP).Results:Among 51 infants with HCMV infection,25.49% of them were systemic ... |
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| Keywords: | Human cytomegalovirus Infant Glycoprotein B Clinical manifestation Genotype |
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