目标导向液体治疗对重度子痫前期母儿预后的影响

目的:探讨目标导向液体治疗(GDFT)对重度子痫前期(SPE)患者母儿的影响。方法:收集2010年4～12月住院的SPE患者60例,随机分为A、B两组各30例。A组给予解痉、降压及镇静的常规治疗;B组在常规治疗的基础上给予GDFT,使中心静脉压(CVP)8～12 mmHg,平均动脉压(MAP)65～90 mmHg,尿量≥0.5 m l/kg.h,中心静脉血氧饱和度(ScvO2)≥75%。比较两组产妇产时、产后并发症及新生儿结局。结果:B组产妇的产时、产后并发症如心力衰竭、肺水肿、产后出血和弥散性血管内凝血(D IC)的发生率比A组显著降低(P<0.05);B组胎儿发育受限、早产儿及早产儿并发症发生率亦明显低于A组(P<0.05),而新生儿Apgar评分8～10分的例数则显著多于A组(P<0.05)。结论:个体化的GDFT能够严格控制SPE患者的液体平衡,改善患者低血容量状态,从而在一定程度上减少产时、产后并发症,延长胎龄,改善新生儿结局。

Effect of goal-directed fluid therapy on prognosis of pregnant women with severe preeclampsia and their neonates

Objective:To explore the effect of goal-directed fluid therapy(GDFT) on prognosis of pregnant women with severe preeclampsia and their neonates.Methods:60 patients with severe preeclampsia who hospitalized in the hospital from April to December in 2010 were collected,then they were divided into A group and B group,30 patients in each group.The patients in A group were treated with conventional treatment including spasmolysis,depressurization and sedative;and the patients in B group were treated with GDFT on...