VEGF-C和FLT-4在乳腺癌中的表达及与淋巴结转移的相关性

目的:探讨人类乳腺癌血清中VEGF-C和FLT-4的表达与乳腺癌淋巴结转移的关系。方法:采用ELISA方法对75例乳腺癌患者和30例乳腺良性肿瘤患者的血清进行VEGF-C和FLT-4水平的检测。结果:乳腺癌组VEGF-C表达水平为(788.13±40.09)pg/ml,高于乳腺良性肿瘤组的(317.35±43.26)pg/ml,乳腺癌组FLT-4水平为(564.39±67.06)pg/ml,高于乳腺良性肿瘤组的(353.62±58.47)pg/ml,差异均有统计学意义(P<0.05);有淋巴结转移乳腺癌患者VEGF-C浓度为(1054.26±215.48)pg/ml,FLT-4浓度为(730.45±142.87)pg/ml,高于无淋巴结转移乳腺癌患者,差异有统计学意义(P<0.05);手术后2周乳腺癌患者VEGF-C和FLT-4浓度分别为(362.41±97.65)pg/ml、(324.58±76.54)pg/ml,低于术前水平,差异有统计学意义(P<0.05)。结论:检测VEGF-C和FLT-4水平可以辅助判断乳腺癌淋巴结转移情况。

The correlative study between lymph nodes metastasis and the expression of VEGF-C and FLT-4 of breast cancer patients

Objective:To study the relationship between lymph nodes metastasis and the expression of VEGF-C and FLT-4 in serum of breast cancer patients.Methods:The protein level of VEGF-C and FLT-4 in serum of 75 breast cancer patients and 30 benign breast tumor patient were determined by ELISA.Results:Serum VEGF-C level(788.13±40.09) pg/ml of breast cancer patients were higher than that of benign breast tumor patient(317.35±43.26)pg/ml,and serum FLT-4 level of breast cancer patients(564.39±67.06)pg/ml were higher than that of benign breast tumor patient(353.62±58.47)pg/ml,and statistics differences were significant(P<0.05).Serum VEGF-C level(1 054.26±215.48) pg/ml and FLT-4 level(730.45±142.87)pg/ml of breast cancer patients with lymph nodes metastasis were higher than those((635.42±183.41) pg/ml and(418.50±109.44) pg/ml) of breast cancer patients without lymph nodes metastasis patient.Serum level of VEGF-C and FLT-4((362.41±97.65)pg/ml and(324.58±76.54) pg/ml) after operation about 2 weeks were lower than those before operation,and statistics differences were significant(P<0.05).Conclusion:The detection of VEGF-C and FLT-4 may assist to judge lymph nodes metastasis of breast cancer patients.