| 子痫前期患者蜕膜中CD4~+ CD25~+ Foxp3~+调节性 T细胞及NK细胞的相关研究 |
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| 引用本文： | 王莲莲,蒋宏颉,魏军.子痫前期患者蜕膜中CD4~+ CD25~+ Foxp3~+调节性 T细胞及NK细胞的相关研究[J].中国妇幼保健,2011,26(16):2505-2507. |
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| 作者姓名： | 王莲莲 蒋宏颉 魏军 |
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| 作者单位： | 1. 中国医科大学附属第四医院,辽宁,沈阳,110032
2. 中国医科大学附属盛京医院 |
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| 摘 要： | 目的:对子痫前期(PE)患者蜕膜中CD4+CD25+Foxp3+调节性T细胞(CD4+CD25+Foxp3+Treg)和NK细胞进行相关研究,探讨子痫前期发病机制中相关的免疫学变化。方法:选择子痫前期患者30例(轻度13例、重度17例)、正常晚期妊娠妇女30例。采用免疫组织化学法检测胎盘蜕膜CD4+CD25+Foxp3+调节性T细胞和NK细胞后计数并检测其平均灰度值。结果:①子痫前期患者蜕膜CD4+CD25+Foxp3+Treg细胞阳性表达率均明显低于正常晚期妊娠者(P均<0.05);②子痫前期患者蜕膜NK细胞数高于正常孕妇(P均<0.05)且NK细胞CD56组化染色平均灰度值高于正常孕妇(P均<0.05)。结论:子痫前期患者蜕膜的CD4+CD25+Foxp3+Treg细胞均低于正常孕妇;蜕膜的NK细胞数均高于正常孕妇,这一结果造成母胎免疫耐受失衡且NK细胞呈激活状态,杀伤活性增强,导致子痫前期。
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| 关 键 词： | 蜕膜 调节性T细胞 NK细胞 子痫前期 |
Study on the correlation between CD4~+ CD25~+ Foxp3~+ T regulatory cells and NK cells in decidual tissues of patients with preeclampsia |
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| WANG Lian-Lion,JIANG Hong-Jie,WEI Jun.Study on the correlation between CD4~+ CD25~+ Foxp3~+ T regulatory cells and NK cells in decidual tissues of patients with preeclampsia[J].Maternal and Child Health Care of China,2011,26(16):2505-2507. |
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| Authors: | WANG Lian-Lion JIANG Hong-Jie WEI Jun |
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| Institution: | WANG Lian-Lian,JIANG Hong-Jie,WEI Jun.The Fourth Hospital Affiliated to China Medical University,Shenyang 110032,Liaoning,China |
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| Abstract: | Objective:To study the correlation between CD4+CD25+ Foxp3+ T regulatory cells and NK cells in decidual tissues of patients with preeclampsia,explore the related immune changes in pathogenesis of preeclampsia.Methods:30 cases with preeclampsia(13 cases with mild preeclampsia and 17 cases with severe preeclampsia) and 30 normal pregnant women of late pregnancy were selected.Immunohistochemical method was used to detect and calculate CD4+CD25+ Foxp3+ T regulatory cells and NK cells in decidual tissues,the ave... |
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| Keywords: | Decidua Regulatory T cells NK cells Preeclampsia |
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