| 子宫内膜异位症患者在位内膜细胞凋亡特性 |
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| 引用本文： | 娄华,王宝金,郝大勇.子宫内膜异位症患者在位内膜细胞凋亡特性[J].中国妇幼保健,2011,26(22):3486-3488. |
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| 作者姓名： | 娄华 王宝金 郝大勇 |
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| 作者单位： | 郑州大学第三附属医院生殖医学科(河南郑州),450052 |
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| 摘 要： | 目的:探讨子宫内膜异位症(EMs)在位内膜细胞凋亡特性的改变。方法:①应用免疫组化方法对32例EMs在位子宫内膜组织及24例对照组子宫内膜组织的Survivin蛋白及Ki-67蛋白的表达进行测定;②应用TUNEL技术监测两组子宫内膜细胞的凋亡特性。结果:EMs在位内膜组织Survivin蛋白表达高于对照组,差异有统计学意义(P<0.05);EMs在位内膜细胞分泌期凋亡指数低于同期对照组子宫内膜,差异有统计学意义(P<0.05);EMs在位内膜组织Ki-67蛋白表达与对照组差异无统计学意义(P>0.05)。结论:EMs在位子宫内膜细胞因凋亡能力下降并非高度增殖导致细胞活性升高,在位内膜细胞的生物学特性改变在EMs的病理生理中可能起着重要作用。
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| 关 键 词： | 子宫内膜异位症 细胞凋亡 Survivin Ki-67 TUNEL |
The features of cell apoptosis of eutopic endometrium in patients with endometriosis |
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| LOU Hua,WANG Bao-Jin,HAO Da-Yong.The features of cell apoptosis of eutopic endometrium in patients with endometriosis[J].Maternal and Child Health Care of China,2011,26(22):3486-3488. |
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| Authors: | LOU Hua WANG Bao-Jin HAO Da-Yong |
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| Institution: | LOU Hua,WANG Bao-Jin,HAO Da-Yong.Department of Reproductive Medicine,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,He'nan,China |
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| Abstract: | Objective:To explore the change of cell apoptosis features of eutopic endometrium in patients with endometriosis.Methods:Immunohistochemical method was used to detect the expression levels of Survivin protein and Ki-67 protein in eutopic endometrium of 32 cases with endometriosis and endometrium of 24 cases in control group;TUNEL technology was used to monitor the features of cell apoptosis of endometrium in the two groups.Results:The expression level of Survivin protein in endometriosis group was significa... |
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| Keywords: | Endometriosis Cell apoptosis Survivin Ki-67 TUNEL |
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