补佳乐联合米索前列醇片治疗稽留流产的临床观察

目的:探讨补佳乐联合米索前列醇在稽留流产中的应用效果。方法:将156例稽留流产患者随机分为3组,每组52例。补佳乐组:口服补佳乐5 mg,每天3次,共3天,第4天早晨阴道内放置米索前列醇片600 g,观察2～6 h后B超下行清宫术;单用米索前列醇组:直接阴道内放置米索前列醇片600 g,行清宫术;米非司酮组:口服米非司酮50 mg,每天2次,共2天,第3天阴道内放置米索前列醇片600 g,行清宫术。观察3组胚胎自然排出情况、是否急诊清宫、宫颈扩张程度、手术时间、术中出血量及清宫后阴道出血持续时间。结果:3组中补佳乐组和米非司酮组胚胎自然排出率分别为67.3%、78.8%,宫颈扩张满意率分别为96.2%、98.1%,两组间比较无统计学差异(P>0.05),两组与米索前列醇组比较有统计学差异(P<0.05)。米非司酮组有9例需要急诊清宫,与补佳乐组和单用米索前列醇组相比有统计学差异(P<0.05)。单用米索前列醇组手术时间最长(P<0.05)。术中出血以补佳乐组最少,单用米索前列醇组最多,3组比较有统计学差异(P<0.05)。结论:补佳乐配伍米索前列醇片治疗稽留流产效果满意,值得在临床上推广。

Clinical observation on missed abortion treated with estradiol valerate combined with misoprostol

Objective:To explore the clinical efficacy of estradiol valerate combined with misoprostol in treatment of missed abortion.Methods:156 patients with missed abortion were divided into 3 groups randomly,52 patients in each group.The patients in estradiol valerate group were treated with oral administration of estradiol valerate,5 mg once,three times a day for 3 days,on the morning of the fourth day,600 g misoprostol were placed into vagina,then curettage of uterine cavity under type B ultrasound were performe...