| 蛋白酶体抑制剂MG132诱导肿瘤细胞凋亡机制的研究进展 |
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| 引用本文： | 饶敏,张淑玲,熊莉娟.蛋白酶体抑制剂MG132诱导肿瘤细胞凋亡机制的研究进展[J].医学分子生物学杂志,2005,2(4):298-301. |
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| 作者姓名： | 饶敏 张淑玲 熊莉娟 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院传染科,武汉市,430030 |
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| 摘 要： | MG132(Z-Leu-Leu-Leu-CHO)是一种蛋白酶体抑制剂,能进入细胞中可逆性地抑制蛋白酶体的活性,从而抑制泛素—蛋白酶体通路所介导蛋白质的降解,进而影响细胞周期进程和诱导细胞凋亡。目前,许多文献报道MG132能够诱导多种肿瘤细胞发生凋亡,是一种潜在的抗肿瘤药物。
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| 关 键 词： | MG132 蛋白酶体抑制剂 肿瘤 |
| 修稿时间： | 2004年12月13 |
Advances in the Research of Mechanism of Apoptosis of Tumorous Cells Induceded by Proteasome Inhibitor MG132 |
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| Rao Min,ZHANG Shuling,XIONG Lijuan.Advances in the Research of Mechanism of Apoptosis of Tumorous Cells Induceded by Proteasome Inhibitor MG132[J].Journal of Medical Molecular Biology,2005,2(4):298-301. |
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| Authors: | Rao Min ZHANG Shuling XIONG Lijuan |
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| Affiliation: | RAO Min,ZHANG Shuling,XIONG Lijuan Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China |
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| Abstract: | MG132 (Z-Leu-Leu-Leu-CHO) is an inhibitor of proteasome, and it can enter the cell to reversibly inhibit the activation of proteasome, thereby influencing the course of cell cycle and inducing the apoptosis of cells. Currently, it has been reported that MG132 can induce apoptosis of all kinds of tumorous cells and can be used a anti-tumor drug. This article reviews the mechanisms of the apoptosis of the tumorous cells induced by MG132. |
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| Keywords: | MG132 proteasome inhibitor tumor |
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