血红蛋白水平对晚期胃癌患者化疗疗效及预后的影响

目的 探讨化疗前血红蛋白（Hb）水平对晚期胃癌患者化疗疗效及预后的影响.方法 选择2008年1月～2012年1月期间新乐市社会保险职工医院收治的86例晚期胃癌患者作为研究对象,所有患者均接受SOX化疗方案至少2个周期,化疗前及化疗2个周期后测定Hb值,比较化疗前不同年龄、性别、ECOG评分、肿瘤分化程度、不同位置肿瘤患者Hb值,并比较86例患者化疗前后的Hb值、有效和无效患者化疗前Hb值及贫血患者和非贫血患者的化疗有效率,对患者随访观察,比较贫血患者和非贫血患者生存时间.结果 化疗前不同年龄、性别、ECOG评分、肿瘤分化程度、不同位置肿瘤患者Hb含量差异均无统计学意义（t/F值=0.568～0.904,P值均＞o.05）,发生内脏转移、腹腔转移患者Hb值分别高于无内脏转移、无腹腔转移患者[（116.9±19.5）g/L vs （107.2±18.7）g/L,（116.5±18.6）g/L vs （106.1±19.8）g/L;t=2.301,2.221,P=0.024,o.029];化疗前86例患者Hb值高于化疗后[（111.3±18.6）g/L vs （104.5±17.8）g/L,t=2.449,P=o.015];所有患者中化疗后有效36例,无效50例,有效患者化疗前Hb值高于无效患者[（115.8±18.7）g/L vs（106.3±17.4）g/L;t=2.421,P=0.018];化疗前58例患者贫血,28例患者不存在贫血,化疗前非贫血患者有效率高于贫血患者（57.1％ vs 34.5％,Z=3.984,P=0.046）,平均生存时间稍长于贫血患者[（463.6±156.4）天vs （397.1±149.8）天,t=1.902,P=0.061）].结论 晚期胃癌患者Hb含量降低,伴有贫血患者化疗疗效及预后较差.

Impact of Hemoglobin Level on Efficacy of Chemotherapy for Advanced Gastric Cancer and Prognosis

Objective To investigate the effect of hemoglobin （Hb） before chemotherapy levels on the curative effect and prognosis in patients with advanced gastric cancer.Methods 86 patients with advanced gastric cancer in Xinle City Social Insurance Workers Hospital from January,2008 to January,2012 were included in this study,all the patients accepted two cycles of SOX chemotherapy at least,measured Hb values of all patients before chemotherapy and in two cycles after chemotherapy,compared Hb values of the patients in different ages,sexes,ECOG scores,the different degrees of tumor differentiation before treatment,and compared Hb values of 86 patients before and after chemotherapy,active and inactive patients before chemotherapy and compared the efficiency of patients with anemia and non anemia and the patients were followed up,compared the survival time of the patients with anemia and non anemia.Results There were no significant differences in different ages,sexes,ECOG scores,the different degrees of tumor differentiation and Hb content in patients with different tumor location before chemotherapy （t/F=0.568～0.904,P＞0.05）,Hb value of the patients with visceral metastasis and peritoneal metastasis were higher than those without metastases[（116.9±19.5）g/L vs （107.2±18.7）g/L,（116.5 ±18.6） g/L vs（106.1±19.8）g/L,t=2.301,2.221,P=0.024,0.029];Hb value of 86 patients before chemotherapy was higher than that after chemotherapy[（111.3±18.6）g/L vs （104.5±17.8）g/L,t=2.449,P=0.015];36 cases were effective and 50 cases were ineffective in all patients after chemotherapy,Hb value of the effective chemotherapy on patients was higher than those of ineffective chemotherapy on patients [（115.8±18.7）g/L vs （106.3±17.4）g/L,t=2.421,P=0.018] ;Anemia was in 58 patients before chemotherapy and 28 patients without anemia.The effective rate of chemotherapy in patients without anemia was higher than that of the patients with anemia （57.1％ vs 34.5 ％,x2 =3.984,P=0.046）.The patients without an