上海地区中老年男性晨尿阿尔茨海默病相关神经丝蛋白水平分析 |
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引用本文: | 潘逸茹,;喻红之,;薛惠君,;陆元善.上海地区中老年男性晨尿阿尔茨海默病相关神经丝蛋白水平分析[J].陕西医学检验,2014(4):62-64. |
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作者姓名: | 潘逸茹 ;喻红之 ;薛惠君 ;陆元善 |
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作者单位: | [1]复旦大学附属华东医院检验科,上海200040; [2]上海交通大学附属第一人民医院输血科,上海200080 |
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摘 要: | 目的 调查上海地区中老年男性晨尿阿尔茨海默病相关神经丝蛋白(AD7c-NTP)水平与年龄的关系.方法 收集432例中老年男性体检人群中段晨尿,根据患者年龄分组,采用双抗体夹心法测定尿液AD7c NTP浓度,分析尿液AD7c NTP浓度分布及其与年龄的关系.结果 上海地区中老年男性晨尿AD7c NTP浓度呈偏态分布,测定结果中位数为0.478 μg/L,范围为0.001~9.58 μg/L,90岁以上年龄组晨尿AD7c NTP浓度显著高于其他年龄组(P<0.05),晨尿AD7c NTP浓度与年龄的相关系数为0.236(P=0.00).结论 晨尿AD7c NTP浓度与年龄相关,如用于AD辅助诊断需进一步规范合格样本标准和评估其临床诊断价值.
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关 键 词: | 中老年男性 晨尿 阿尔茨海默病相关神经丝蛋白 |
Analysis of Morning Urine Alzheimer-Associated Neuronal Thread Protein in Shanghai Middle-aged Men |
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Institution: | PAN Yi-ru,YU Hong-zhi,XUE Hui-jun,LU Yuan-Shan(Department of Clinical Laboratory, Huadong Hospital of Fu Dan University,Shanghai 200040, China;Department of Blood Transfusion, the First People's Hospital of Shanghai Jiaotong University, Shanghai 200080, China) |
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Abstract: | Objective To investigate the relationship between the concentration of morning urine Alzheimer associated neuro nal thread protein (AD7c NTP) and age in Shanghai middle-aged men.Methods Collected 432 mid-stream urine samples in middle aged men from health examination population and grouped samples by the patient's age.Measured urine AD7c-NTP concentrations with double antibodies sandwich method.Analysed the distribution of urine AD7c-NTP concentrations and the relationship between the concentrations and patient's age.Results It was skewed distribution for urine AD7c-NTP concentrations in Shanghai middle aged men.The median of urine AD7c NTP concentration was 0.478 μg/L.The minimum and maximum values of urine AD7c NTP concentration were 0.001 to 9.58 μg/L,respectively.The concentrations of urine AD7c NTP in 90 years of age or older age group were higher than other age groups (P<0.05).The spearman correlation coefficient was 0.236 between urine AD7c NTP concentration and patient's age (P=0.00).Conclusion There was a relationship between morning urine AD7c NTP concentration and patient's age.It's necessary to further qualify sample standards and evaluate its clinical diagnostic values when morning urine AD7c-NTP concentrations would be used for clinical AD auxiliary diagnosis. |
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Keywords: | middle-aged men morning urine Alzheimer-associated neuronal thread protein |
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