非酒精性脂肪肝病与血脂的相关性研究

目的:探讨非酒精性脂肪肝病(NAFLD)与血脂的相关性。方法:研究对象均为2010~2011年在本院进行体检的武汉大学教职员工,内容包括询问病史、体格检查、生化检查、肝脏彩超检查。将研究对象分为NAFLD组和非脂肪肝组,分析两组的人口学特征及血脂水平,采用Logistic回归模型分析,评价血脂水平在非酒精性脂肪肝的意义。结果:NAFLD组较非脂肪肝组TG,、TC、LDL-C水平高;而观察HDL-C水平,NAFLD组较非脂肪肝组为低,差异有统计学意义;NAFLD组合并高甘油三酯血症、高胆固醇血症、低高密度脂蛋白血症均较非脂肪肝组高,差异有显著性(0.001),其中高甘油三酯血症最为显著;Logistic回归分析显示,非酒精性脂肪肝病与TG、TC、LDL-C显著相关。结论:武汉大学教工体检人群NAFLD与TC、TG及LDL-C密切相关。

The Study of the Relativity between Nonalcoholic Fatty Liver Disease and Serum Lipid

Objective：To analyze the relativity between nonalcoholic fatty liver disease and serum lipid level n among 9094persons.Methods：The survey was conducted among the staff of Wuhan University from2010to 2011in Hospital of Wuhan University The participants had serum lipids（TCTGHDI-CLDL-C）test,and routine liver ultrasonography.The results of cases of nonalcoholic fatty liver disease were compared with those without nonalcoholic fatty liver disease.Then using logistic regression analysis search for the risk factors of non-alcoholic fatty liver patients.Results：The ratio of nonalcoholic fatty liver disease cases was20.7%,and the prevalence of nonalcoholic fatty liver disease in males（25.9%）was higher than that of females（15.2%）.The population with nonalcoholic fatty liver disease had higher levels of TG,TC,LDL-C and lower level of HDL-C than those without nonalcoholic fatty liver disease.Logistic regression analysis showed that nonalcoholic fatty liver disease was positively correlated to TG,TC and LDL-C.Conclusion：The serum lipid level is associated with nonalcoholic fatty liver disease,especially TG is relatively high associated which is independent risk factor in NAFLD.