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A movable microelectrode array for chronic basal ganglia single-unit electrocorticogram co-recording in freely behaving rats |
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| Authors: | Xiaobin Zheng Jia Zeng Ting Chen Yuanxiang Lin Lianghong Yu Ying Li Zhangya Lin Xiyue Wu Fuyong Chen Dezhi Kang Shizhong Zhang |
| Affiliation: | 1. Department of Neurosurgery, Key Clinic Specialty Discipline of Fujian, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China 2. Center for Biosignatures Discovery Automation, The Biodesign Institute, Arizona State University, Tempe, AZ, USA 3. Department of Radiotherapy, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China 4. Intensive Care Unit, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China 5. Department of Neurosurgery, Institute of Neurosurgery, National Key Clinic Department, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China |
| Abstract: | The basal ganglia–cortical circuits are important for information process to brain function. However, chronic recording of single-unit activities in the basal ganglia nucleus has not yet been well established. We present a movable bundled microwire array for chronic subthalamic nucleus (STN) single-unit electrocorticogram co-recording. The electrode assembly contains a screw-advanced microdrive and a microwire array. The array consists of a steel guide tube, five recording wires and one referenced wire which form the shape of a guiding hand, and one screw electrode for cortico-recording. The electrode can acquire stable cortex oscillation-driven STN firing units in rats under different behaving conditions for 8 weeks. We achieved satisfying signal-to-noise ratio, portions of cells retaining viability, and spike waveform similarities across the recording sections. Using this method, we investigated neural correlations of the basal ganglia–cortical circuits in different behaving conditions. This method will become a powerful tool for multi-region recording to study normal statements or movement disorders. |
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