Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats |
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| Authors: | Zubareva O E Krasnova I N Abdurasulova I N Bluthe R M Dantzer R Klimenko V M |
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| Affiliation: | Institute for Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia. |
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| Abstract: | The ability of the brain serotonergic system to mediate the effects of interleukin-1beta (IL-1beta) was investigated. Intracerebroventricular administration of IL-1beta induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity. |
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