| 福建汉族人群卸LA-DRB1等位基因多态性研究 |
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| 引用本文： | 王庆华 陈威震 谭建明. 福建汉族人群卸LA-DRB1等位基因多态性研究[J]. 中华医学遗传学杂志, 2006, 23(2): 240-241 |
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| 作者姓名： | 王庆华 陈威震 谭建明 |
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| 作者单位： | 南京军区福州总医院器官移植研究所实验室,福州350025 |
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| 基金项目： | 全军“十五”课题.医学杰出人才基金（01J003）;上海市科委重大课题（024919005） |
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| 摘 要： | 目的调查福建汉族人群HLA-DRB1等位基因的多态性。方法应用寡核苷酸基因芯片分型技术对福建地区620名汉族人群进行HLA-DRB1位点的基因分型。结果在HLA-DRB1位点共检出了14种等位基因，基因频率较高的依次为DRB1＊09、12、15、04、08。结论福建汉族HLA-DRB1等位基因多态性与南方汉族人群相近，但也有其独特的特点。
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| 关 键 词： | 人类白细胞抗原 遗传多态性 基因分型 |
| 收稿时间： | 2005-05-08 |
Analysis of HLA-DRBI allele polymorphism in the Fujian Hall nationality population of China |
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| WANG Qing hua, CHEN Wei-zhen, TAN Jian-ming.. Analysis of HLA-DRBI allele polymorphism in the Fujian Hall nationality population of China[J]. Chinese journal of medical genetics, 2006, 23(2): 240-241 |
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| Authors: | WANG Qing hua CHEN Wei-zhen TAN Jian-ming. |
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| Affiliation: | Department of Urology, Fuzhou General Hospital, Nanjing Command of PLA, Fuzhou, Fujian, 350025 P. R. China |
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| Abstract: | OBJECTIVE: To investigate the HLA-DRB1 allele polymorphism in Fujian Han nationality population. METHODS: Six hundred and twenty individual samples collected from unrelated Fujian Han population were subjected to genotyping using oligonucleotide microarray technique. And the allele frequencies of HLA-DRB1 were calculated and compared with other populations. RESULTS: Fourteen HLA-DRB1 alleles of Fujian Han population were detected. The gene frequencies ordered from high to low were HLA-DRB1*9, 12, 15, 4, 8 respectively. CONCLUSION: The HLA-DRB1 distribution of Fujian Han population shares some genetic characters with southern Chinese Han populations, but these characters differ from northern Chinese populations. |
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| Keywords: | human leukocyte antigen genetic polymorphism genotyping |
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