冠心病患者一氧化氮、氧化型低密度脂蛋白和细胞间粘附分子-1与冠状动脉狭窄间的关系

为探讨一氧化氮、氧化型低密度脂蛋白和细胞间粘附分子 - 1与冠心病患者病情变化的关系 ,本文检测了 81例冠心病患者和 35例冠状动脉无病变者外周血清中一氧化氮、氧化型低密度脂蛋白和细胞间粘附分子 - 1水平的变化 ,并进行对比分析。结果发现 ,冠心病组一氧化氮水平低于无病变组 ,而氧化型低密度脂蛋白和细胞间粘附分子 - 1水平高于无病变组 ,差异有显著性 (P <0 .0 5 )。冠心病组一氧化氮水平随冠状动脉狭窄支数的增多而降低 (P <0 .0 0 1) ,氧化型低密度脂蛋白与细胞间粘附分子 - 1水平随冠状动脉狭窄支数的增多而增高 (P <0 .0 5 )。相关分析发现 ,一氧化氮与氧化型低密度脂蛋白与细胞间粘附分子 - 1呈负相关 (r=- 0 .199和r =- 0 .2 34 ,P <0 .0 5 ) ,而氧化型低密度脂蛋白和细胞间粘附分子 - 1呈正相关 (r=0 .378,P <0 .0 1)。结果提示 ,一氧化氮、氧化型低密度脂蛋白和细胞间粘附分子 - 1与冠心病的发病和病情变化密切相关。

The Relationship between Serum Levels of Nitric Oxide, Oxidized Low Density Lipoprotein, Intercellular Adhesion Molecule-1 and Coronary Stenosis in Patients with Coronary Heart Disease

Aim To study the relationship between nitric oxide (NO), oxidized low density lipoprotein (ox-LDL), intercellular adhesion molecule-1 (ICAM-1) and coronary stenosis in patients with coronary heart disease (CHD). Methods The levels of NO, ox- LDL, ICAM-1 of peripheral serum were determined in 81 CHD patients and 35 controls. Results The levels of NO were significantly lower in CHD group than controls, while the levels of ox-LDL and ICAM-1 were higher in CHD group than controls (P<0.05). The levels of NO in CHD patients declined with the increasing extent of coronary stenosis (P<0.001). The levels of ox-LDL and ICAM-1 increased with the increasing extent of coronary stenosis (P<0.05). NO was negatively related to ox-LDL and ICAM-1 (r=-0.199 and r=-0.234, P<0.05), ox-LDL was positively related to ICAM-1 (r=0.378, P<0.01). Conclusion The data suggests that the levels of serum NO, ox-LDL and ICAM-1 are associated with the occurrence and progression of CHD.