工业毒物与肝脏混合功能氧化酶的相互影响

为探讨工业毒物与肝脏混合功能氧化酶（ＭＦＯ）的相互影响规律，从中寻找对人体影响的监测依据，进行了实验研究与现场研究。结果发现：在各种实验染毒条件下，不同毒物可导致ＭＦＯ活力的多样化改变：诱导或抑制、单相或双相反应等，毒物毒性可随之改变；ＭＦＯ还参与多种毒物代谢，与多种肝毒机制有关，如脂质过氧化作用、肾上腺皮质功能改变及肝细胞大分子共价结合作用等，其中人体ＭＦＯ对毒物的反应规律，有望提供肝脏毒物对人体影响的监测指标。

Study on the interaction pattern between certain industrial toxicants and liver mixed function oxidases

Objectives: To comparatively analyze the long_term outcome of anterior and posterior approach discectomy and provide a the thoretical basis for the clinics application. Methods: The Roland and Greenough rating system and a few relative items were used to analyse the patients who undergone first discectomy in our hospital between 1984 and 1991. Of these, anterior approach was used in 67 cases, posterior in 136. The follow_up period was 3 to 11 years. Results: It showed that the anterior approach discectomy had the shorter operative time, less bleeding,less opterative complication and faster recoverage. The long term result of anterior approach was also better than that of posterior. The analysis by illness duration and age showed that there were no significant effect on the results. Conclusions: The authors point out that for the patients who have the indication of discectomy, especially for those labor worker, the anterior approach disectomy is a better choice.