Immune escape through C-type lectins on dendritic cells |
| |
Authors: | Engering Anneke Geijtenbeek Teunis B H van Kooyk Yvette |
| |
Affiliation: | Dept. of Molecular Cell Biology, VU Medical Center, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. |
| |
Abstract: | Dendritic cells (DCs) detect different pathogens and elicit tailored anti-microbial immune responses. They express C-type lectins that recognise carbohydrate profiles on microorganisms, resulting in internalisation, processing and presentation. Intracellular sequences of distinct DC-specific lectins point to differences in intracellular routing that influence antigen presentation. Moreover, putative signalling motifs hint to the activation of DCs on carbohydrate recognition. Recent evidence shows that not only pathogens, but also tumour antigens, exploit C-type lectins to escape intracellular degradation resulting in abortive immunity. More insight into ligand specificity, intracellular targeting and signalling will reveal the pathways by which pathogens modulate immunity through C-type lectins. |
| |
Keywords: | dendritic cells pathogens Toll-like receptors C-type lectins carbohydrates DC-SIGN HIV-1 mycobacteria Immunology Cell biology |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|