| LOXL2与心血管疾病关系的研究进展 |
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| 引用本文： | 孙陈琛,邵晨,杜荣增. LOXL2与心血管疾病关系的研究进展[J]. 南华大学学报(医学版), 2022, 0(4): 618-620, 624 |
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| 作者姓名： | 孙陈琛 邵晨 杜荣增 |
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| 作者单位： | 江苏大学附属医院心内科,江苏省镇江市 212001 |
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| 基金项目： | 江苏省自然科学基金项目(BK20201225)；镇江市社会发展项目(SH2019043) 作者简介:孙陈琛,硕士研究生,住院医师,研究方向为心房颤动的发生和维持机制研究,E-mail为SCC19950610@163.com。通信作者杜荣增,博士,副教授,主任医师,硕士研究生导师,研究方向为心房颤动的发生和维持机制研究,E-mail为dubingchen001@foxmail.com。 |
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| 摘 要： | 赖氨酰氧化酶样蛋白2(LOXL2)是赖氨酰氧化酶家族的一员,具有促进胶原蛋白和弹性蛋白交联,维持细胞外基质稳定性的作用。LOXL2参与心血管系统的纤维化过程,可诱发心力衰竭、心房颤动、高血压等心血管疾病。敲除LOXL2基因或使用LOXL2抑制剂可以改善心功能和降低血压。
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| 关 键 词： | 赖氨酰氧化酶样蛋白2 心血管疾病 纤维化 |
| 收稿时间： | 2022-01-29 |
| 修稿时间： | 2022-04-28 |
Research progress on the relationship between LOXL2 and cardiovascular disease |
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| SUN Chenchen,SHAO Chen,DU Rongzeng. Research progress on the relationship between LOXL2 and cardiovascular disease[J]. Journal of Nanhua University(Medical Edition), 2022, 0(4): 618-620, 624 |
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| Authors: | SUN Chenchen SHAO Chen DU Rongzeng |
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| Affiliation: | Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu, China |
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| Abstract: | As a member of the lysyl oxidase family, lysyl oxidase-like 2(LOXL2) can promote cross-linking between collagen and elastin and maintains the stability of the extracellular matrix. LOXL2 is involved in the fibrotic process of the cardiovascular system and can induce cardiovascular diseases such as heart failure, atrial fibrillation and hypertension. LOXL2 gene knockout or LOXL2 inhibitor can improve cardiac function and reduce blood pressure. |
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| Keywords: | lysyl oxidase-like 2 cardiovascular disease fibrosis |
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