SGK1在日光性角化病、基底细胞癌及鳞状细胞癌中的表达

目的：检测SGK1在日光性角化病（AK）、基底细胞癌（BCC）及鳞状细胞癌（SCC）中的表达。方法：采用免疫组化SABC法检测SGK1在25例正常皮肤(NS)、25例AK、28例BCC、28例皮肤鳞状细胞癌标本中的表达。结果：NS、AK、BCC和SCC标本中，SGK1阳性细胞率分别为（40.03±14.42）%，（36.63±14.28）%，（52.82±18.73）%和（52.58±20.13）%。BCC组和SCC组分别与NS组比较，差异均有统计学意义（Ps<0.05）。各组SGK1染色阳性细胞率>50%的标本分别为6例（24%），3例（12%），16例（57.14%）和14例（50%）,BCC组和SCC组分别与NS组比较，差异均有统计学意义（Ps<0.05）。结论：SGK1的高表达可能与基底细胞癌及鳞状细胞癌的发病有关。

Expression of SGK1 in actinic keratosis,basal cell carcinoma and squamous cell carcinoma

Objective: To detect the expression of SGK1 in the lesions of actinic keratosis (AK)，basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Methods: The expression levels of SGK1 were detected by immunohistochemical SABC method in the samples of 25 normal skin (NS), 25 AK, 28 BCC and 28 SCC. Results: In the samples of NS, AK, BCC and SCC，the positivity rates of SGK1 cells were (40.03±14.42)%, (36.63±14.28)%, (52.82±18.73)% and (52.58±20.13)% respectively, and there were significant differences in positivity rates between BCC, SCC group and NS group (Ps<0.05). The cells positivity rate >50% were seen in 6 NS samples (24%), 3 AK (12%)，16 BCC (57.14%) and 14 SCC (50%). The positivity rates were significant differences between BCC, SCC group and NS group (Ps<0.05). Conclusion: SGK1 may play a role in the pathogenesis of basal cell carcinoma and squamous cell carcinoma.