可溶性血管内皮生长因子受体-1与子痫前期相关因素分析

目的　研究可溶性血管内皮生长因子受体- 1 ( sFlt-1) 及临床生化指标在正常妊娠和子痫前期(轻度、重度)组母体外周血中表达差异。方法　选取子痫前期轻度16例、子痫前期重度孕妇24例，18例与之年龄孕周相匹配的血压正常单胎孕妇(对照组) ,用ELISA方法测定其外周血中sFlt-1的水平，检验科常规测量各项生化指标。结果　外周血中sFlt-1水平、血尿酸、血清肌酐、β2微球蛋白在子痫前期重度组明显高于对照组, 分别为(11039.43 ±1305.84) 、（3158.27±2658.13）ng/L ；(379.87 ±82.11) 、（266.41±57.69）μmol/ L；（61.65±12.24) 、（50.87±8.35）μmol/ L；（2.88±0.82）、（1.94±0.49）mg/L；血浆白蛋白水平（29.26±3.92）g/ L低于对照组（35.52±6.92 ）g/ L，以上两者差异均有显著性( P < 0.05) 。血清sFlt-1水平在对照组、子痫前期轻度、子痫前期重度中逐渐升高分别为（3158.27±2658.13）、（6060.75±2992.92 ）、(11039.9 ±1305.84)ng/L。结论　sFlt-1 在子痫前期组孕妇的外周血中表达升高, 可能与子痫前期的病因及病理生理有关，与疾病的严重程度相关，联合其他指标可以作为预测和判断子痫前期疾病严重性的指标。

Association study of preeclampsia and soluble vascular endothelial growth factor receptor-1

Objective 　 To investigate the association between sFlt - 1 and and pre-eclampsia. Methods 　 sFlt-1 concentration of Serum was measured by enzy- me linked immunosorbent assay ( ELISA) in 40 preeclampsia patients(16 cases of mild preeclampsia (mPE group);and 24 cases of severe preeclampsia (sPE group)). 18 normal pregnant wo- men .They are all singleton pregnancies matched with age,gestational age respectively. We collected clinical biochemical indicators from case data. Results concentration of sFlt-1,serum uric acid , β2 microglob- ulin and serum creatinine in severe preeclampsia group were higher than those in control group, respectively are (11039.43 ±1305.84) vs（3158.27±2658.13）ng/L；(379.87 ±82.11) vs （266.41±57.69）μmol/ L；（61.65±12.24) vs（50.87±8.35）μmol/ L；（2.88±0.82）vs（ 1.94±0.49）mg/L； concentration of Plasma albu- min (29.26 + 3.92) g/L was lower than control group (35.52 + 6.92) g/L. significant differences were found ( P < 0.05) between control group and severe preeclampsia group .Serum sFlt - 1 level in the control group, mild preeclampsia, severe preecla- mpsia gradually rise （3158.27±2658.13）、（6060.75±2992.92 ）、(11039.9 ±1305.84)ng/L. Conclusion 　High maternal serum sFlt-1 may relate to the pathogen- nesis and pathophy- siology of preeclampsia and relate to the severity of the disord- er. com- binded with other indicators index maybe predict and judge preeclampsia disease severity.