三亚市农垦南新小学学生HBsAg感染调查及疫苗接种的效果观察

目的　了解南新场部小学生在推广乙肝疫苗接种措施前的感染情况以及措施执行后对HBsAg的免疫效果。　方法　于乙肝疫苗接种措施前的 1995年和措施执行后的 1999及 2 0 0 2年 ,全体学生静脉采血 ,以ELISA方法检查乙肝两对半 ,并发放统一问卷调查表调查学生乙肝疫苗的接种史。　结果　 1995、1999和 2 0 0 2年在校学生分别为 110 5人、113 5人和 10 69人 ,乙肝疫苗接种率为 0、68%和 89%。HBsAg携带率分别为 12 %、7 3 %和 3 6%。三次调查HBsAg的携带率差异均有显著性 (u =3 814 ,P <0 0 0 1)。　结论　将乙肝疫苗的接种纳入儿童计划免疫以及场医院采取可行的鼓励措施后 ,儿童乙肝疫苗接种率明显提高

Observation on the results of vaccination and HBsAg carrying status in primary schoolchildren in Nanxin Farm of Sanya City

Objective To understand the HBsAg carrying status and results of popularization of vaccination of hepatitis B vaccine in primary schoolchildren in Nanxin Farm, Hainan Province Methods Blood samples were taken from the primary schoolchildren in 1995 before the vaccination, 1999 and 2002 after the practice of vaccination and analyzed by ELISA for detection of HBsAg, HBsAb, HBeAg, HBeAb HBcAb Meanwhile the immunization history was surveyed by using structured questionnaires Results The immunization rate in 1995,1999 and 2002 were 0, 68% and 89%, respectively, while the HBsAg carrying rates in the three surveys were 12%, 7 3% and 3 6%, respectively and the differences were significant (u=3 814, P=0 001) Conclusion The rate of immunization of hepatitis B vaccine has been enhanced after vaccination of hepatitis B vaccine in expanded program of immunization in the locality