| 槐花制炭后新止血成分的药理研究 |
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| 引用本文： | 赵雍,郭静,刘婷,李春英,曹春雨,易艳,郝然,李娆娆. 槐花制炭后新止血成分的药理研究[J]. 中国中药杂志, 2010, 35(17): 2346-2349 |
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| 作者姓名： | 赵雍 郭静 刘婷 李春英 曹春雨 易艳 郝然 李娆娆 |
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| 作者单位： | 中国中医科学院,中药研究所,北京,100700 |
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| 基金项目： | 北京市自然科学基金项目(7062050) |
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| 摘 要： | 目的:观察槐花制炭前后饮片、提取物止血作用的改变,以及主要成分、特征性成分的止血作用强度,探索槐花制炭后新的止血成分。方法:以出血时间(BT)和血浆复钙时间(RT)为止血作用的特异性指标,观察槐花生品、炭品,炭品的特征性提取物A和B(SCE A和B)及主要成分灌胃给药后对正常大鼠止血作用的影响,分析其制炭后可能存在的新止血成分。结果:槐花生品,炭品能显著缩短正常大鼠BT和RT,其中炭品作用强于生品。SCE A和SCE B均能显著缩短正常大鼠BT和RT,其中SCE B作用优于SCE A。进一步研究SCE B中提取得到的成分1(槐树皂苷Ⅰ)和2(异鼠李素-3-O-芸香糖苷)及其主要成分(芦丁、鞣质),均能显著缩短正常大鼠BT和RT,其中成分2的作用最优。结论:槐花生品,炭品及槐花制炭后2种提取物和上述4种成分止血作用均显著增加,其中成分2作用显著,提示该成分可能是槐花炭发挥止血作用的新有效成分,也表明槐花炒炭后止血作用增加应是多种成分的协同结果。
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| 关 键 词： | 槐花炭 止血作用 出血时间 血浆复钙时间 |
| 收稿时间： | 2010-01-11 |
Pharmacology experimental study of new hematischesis compounds after Flos Sophorae carbonized |
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| ZHAO Yong,GUO Jing,LIU Ting,LI Chunying,CAO Chunyu,YI Yan,HAO Ran and LI Raorao. Pharmacology experimental study of new hematischesis compounds after Flos Sophorae carbonized[J]. China Journal of Chinese Materia Medica, 2010, 35(17): 2346-2349 |
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| Authors: | ZHAO Yong GUO Jing LIU Ting LI Chunying CAO Chunyu YI Yan HAO Ran LI Raorao |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | |
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| Keywords: | Flos Sophorae Carbonisatus hemostatic effect bleeding time (BT) recalcification time (RT) |
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