CYP4A11基因多态性与心肌梗死相关

目的 研究在不同性别中CYP4A11基因多态性与心肌梗死的关系.方法 166例心肌梗死患者和158例对照组,选择CYPA11基因的3个SNPs(rs9332978、rs3890011和rs1126742),应用TaqMan SNP基因分型法进行基因分型,并应用病例对照的研究方法进行相关性分析.结果 rs3890011的基因分型在心肌梗死组和对照组之间的分布存在明显差异(P＜0.05),心肌梗死组携带GG基因型(GG vs CC+ GC)高于对照组(P＜0.05),在排除吸烟、高血压、糖尿病等混杂因素后,仍存在显著性差异(95％ CI:1.138～2.432,P＜0.01).结论 CYP4A11基因的rs3890011多态性与心肌梗死相关,rs3890011的GG基因型可作为心肌梗死易感基因标记.

CYP gene polymorphism is associated with myocardial infarction

Objective To evaluate potential association between human CYP4A11 gene and myocardial infarction(MI).Methods A total of 166 MI patients and 158 controls were genotyped for 3 single-nucleotide polymorphisms(SNPs) of the human CYP4A11 gene(rs9332978,rs3890011,rs1126742).The data were evaluated via case-control study.Results The distribution of SNP2(rs3890011) genotypes showed significant difference between the MI and control subjects(P<0.05),the distribution of the recessive model of SNP2 was significantly higher in MI patients than control subjects(P<0.05).The significance of the recessive model of SNP2 between MI patients and control subjects retained after adjustment for covariates(95% CI: 1.138～2.432,P<0.01).Conclusionsrs3890011 is a novel polymorphism of CYP4A11 gene associated with MI,GG genotype of rs3890011 functions as a genetic markers of MI.