| 依托红霉素片含量测定方法的改进 |
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| 引用本文： | 钟然,陈画虹. 依托红霉素片含量测定方法的改进[J]. 中国药师, 2001, 4(1): 27-29 |
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| 作者姓名： | 钟然 陈画虹 |
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| 作者单位： | 1. 广东省佛山市药品检验所,528000
2. 广东省中山市妇幼保健院 |
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| 摘 要： | 目的对依托红霉素片含量测定方法进行改进.方法对依托红霉素片含量测定中的样品前处理方法进行改进,取样品适量,精密称定置量瓶中,加乙醇适量溶解(按相当于红霉素2.5mg加乙醇1ml),用磷酸盐缓冲液(p田.8)配制成1000u@mnl-1,静置2h后,按抗生素微生物检定法红霉素项下测定其含量.结果改进法克服了按药典法[1,2]测定时,含量结果不稳定、偏低、易偏离平行的现象.结论改进法准确、稳定、可靠.
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| 关 键 词： | 依托红霉素 含量 测定 片剂 |
| 修稿时间： | 2000-03-08 |
Improvement of Content Determinig Method for Erythromycin Estolate |
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| Zhong Ran. Improvement of Content Determinig Method for Erythromycin Estolate[J]. China Pharmacist, 2001, 4(1): 27-29 |
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| Authors: | Zhong Ran |
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| Abstract: | Objectives: To improve the content determining method for erythromycin estolate. Method: Pretreatment method of sample was improved in the content determination of erythromycin estolate. The sample was scaled accuratly and put into cylinder, ethanol was added into the cylinder (erythromycin estolate 2. 5 mg: ethanol 1 ml), the solution was made-up 1 000 u- ml-1 with phosphate buffer(pH7.8), erythromycin content in which solution was determined 2 h after standing. Result:The unstable or lower content and being easy of deriation from the parallel phenomenon, when it was determined according to pharmacopeial method, were overcome. Conclusion: The improving method is accurate, stable, and reliable. |
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| Keywords: | Erythromycin estolate Content determination |
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