Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and Gemeprost for termination of first trimester pregnancy |
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| Authors: | Olajide, F. Howell, R.J.S. Wass, J.A.H. Holly, J.M.P. Bohn, H. Grudzinskas, J.G. Chapman, M.G. Chard, T. |
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| Affiliation: | Departments of Obstetrics and Gynaecology and Reproductive Physiology St Bartholomew‘s Hospital Medical College and The London Hospital Medical College London, UK 2Department of Endocrinology London, UK 3Department of Chemical Endocrinology, St Bartholomew’s Hospital Medical College London, UK 4Department of Obstetrics and Gynaecology, Guy‘s Hospital London, UK 5Behringwerke 3550 Marburg/Lahn, FRG |
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| Abstract: | First trimester termination of pregnancy was successfully inducedin ten patients with RU 38486 followed 2 days later by a prostaglandin(Gemeprost) pessary. Human chorionic gonadotrophin (HCG) valuesremained unaltered until after the abortion. The levels of placentalprotein 12 (PP12) showed an immediate and significant fall followingRU 38486, then rose to values substantially higher than thoseat the initial visit after 2 days. These findings show thatRU 38486 has a direct inhibitory effect on tissues producingPP12 and confirm the progesterone dependency of this protein |
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| Keywords: | RU 486/Gemeprost/PP12/HCG |
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