| 侵袭性垂体腺瘤中CD44与Ki-67表达的相关性 |
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| 引用本文： | 段波,赵洪洋,李新建,胡学斌,涂汉军. 侵袭性垂体腺瘤中CD44与Ki-67表达的相关性[J]. 肿瘤防治研究, 2006, 33(7): 490-492,F0003. DOI: 10.3971/j.issn.1000-8578.2294 |
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| 作者姓名： | 段波 赵洪洋 李新建 胡学斌 涂汉军 |
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| 作者单位： | 郧阳医学院附属太和医院神经外科; 华中科技大学同济医学院附属协和医院神经外科; 郧阳医学院附属太和医院神经外科 000湖北十堰; |
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| 摘 要： | 目的探讨细胞粘附分子CD44、细胞增值核抗原Ki-67在侵袭性垂体腺瘤中的表达及意义并探讨二者之间的关系。方法用免疫组化法检测CD44s、CD44v5、Ki-67在20例侵袭性垂体腺瘤和18例非侵袭性垂体腺瘤中的表达。结果CD44s和Ki-67在侵袭性垂体腺瘤组中表达高于非侵袭性垂体腺瘤组(P<0.01),且二者在垂体腺瘤中的表达呈正相关。CD44v5在侵袭性和非侵袭性垂体腺瘤中表达无明显差异(P>0.05)。结论CD44s和Ki-67与垂体腺瘤的侵袭性生长行为有关,二者协同作用,在侵袭性垂体腺瘤的发生、发展中起重要作用,可作为侵袭性垂体腺瘤诊断和判断预后的重要生物学指标。
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| 关 键 词： | 侵袭性垂体腺瘤 非侵袭性垂体腺瘤 CD44s CD44v5 Ki-67 |
| 文章编号： | 1000-8578（2006）07-0490-03 |
| 收稿时间： | 2005-07-22 |
| 修稿时间： | 2005-07-222006-03-22 |
Expression and Relationship between CD44 and Ki-67 in Invasive Pituitary Adenoma |
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| DUAN Bo,ZHAO Hong-yang,LI Xin-jian,HU Xue-bin,TU Han-jun. Expression and Relationship between CD44 and Ki-67 in Invasive Pituitary Adenoma[J]. Cancer Research on Prevention and Treatment, 2006, 33(7): 490-492,F0003. DOI: 10.3971/j.issn.1000-8578.2294 |
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| Authors: | DUAN Bo ZHAO Hong-yang LI Xin-jian HU Xue-bin TU Han-jun |
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| Affiliation: | 1.Department of Neurosurgery; Taihe Hospital of Yunyang Medical College; Shiyan 442000; China; 2.Department of Neurosurgery of Xiehe Hospital of Tongji Medical College of Huazhong University of Science and Technology; |
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| Abstract: | Objective To study the expression and role of CD44 and Ki-67 in invasive pituitary adenoma and the relationship between them.Methods The expression of CD44s、CD44v5 and Ki-67 in 20 cases invasive pituitary adenoma and 18 cases non-invasive pituitary adenoma were detected with SP immunohistochemical technique.Results The expressive levels of CD44s and Ki-67 in the invasive pituitary adenomas were significantly higher than those in the non-invasive ones(P<(0.01)),it is positively correlation between them.Th... |
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| Keywords: | CD44s CD44v5 Ki-67 |
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