急性胰腺炎胃肠激素变化的初步研究

目的:观察急性胰腺炎(AP)患者血浆内皮素(ET)、钙基因相关肽(CGRP)、血清胃泌素(GAS)的变化,并探讨这三种“胃肠激素”在AP发病机制中的作用及其临床意义。方法:应用放射免疫法测定29例AP患者治疗前(A组)、治疗后(B组)及22例健康人(C组)血浆ET、CGRP及血清GAS水平。结果:A组血浆ET、CGRP、ET/CGRP、血清GAS水平与B组或C组比较,显著升高(P<0.05或P<0.01)B组三种激素ET/CGRP与C组比较无明显差异(P<0.05)。结论:血浆ET、CGRP、血清GAS在AP时增高,测定血液ET、CGRP及GAS对于AP有相当重要的临床意义。

Preliminary Study of Gastrointestinal Hormones in the Patients with Acute Pancreatitis

Purpose: The levels of serum endothelin (ET), calcitonin generate related peptide(CGRP) and gastrin(GAS) from the patients with acute pancreatitis were observed. The relationship between the levels and pathogenesis, clinical significance were evaluated. Methods: RIA approach were performed to detects the levels of serum ET, CGRT and GAS twenty nine pre and post-treated patients with AP and 22 healthy controls were participated in this study. Results: It is statistical significance when the levels of serum ET, CGRP, ET/CGRT of group A were compared with those of group B,C(P<0. 05; P < 0.01). Conclusions: The levels of serum ET, CGRT, GAS are increased in the patients with AP. The de-tection of serum ET, CGRT, GAS is helpful to the early diagnosis and the instruction of treatment.