Phase II trial of 5-fluorouracil, adriamycin, and mitomycin C in advanced colorectal cancer. |
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Authors: | D G Haller P V Woolley J S Macdonald L F Smith P S Schein |
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Abstract: | Thirty-five patients with advanced measurable colorectal cancer were treated with a combination of 5-fluorouracil (5-FU), adriamycin, and mitomycin C (FAM). Objective regression of tumor was observed in six patients (17%); seven patients (20%) demonstrated stabilization of disease. The FAM regimen was generally well tolerated with toxic effects limited to bone marrow depression and mild-to-moderate nausea and vomiting. FAM combination chemotherapy did not significantly improve survival in responding patients, nor was it more effective than 5-FU alone in achieving objective regression of disease. |
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