| 肺神经内分泌癌的免疫组化与免疫电镜研究 |
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| 引用本文： | 笪冀平,孟如松,李维华,陈乐真,黄靖香.肺神经内分泌癌的免疫组化与免疫电镜研究[J].临床与实验病理学杂志,1993(Z1). |
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| 作者姓名： | 笪冀平 孟如松 李维华 陈乐真 黄靖香 |
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| 作者单位： | 空军总医院病理科 北京100036
(笪冀平，孟如松)，解放军总医院病理科 北京100853
(李维华，陈乐真)，解放军总医院病理科 北京100853(黄靖香) |
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| 摘 要： | 本文应用免疫组化与免疫电镜技术对20例肺神经内分泌癌进行了研究,另6例非神经内分泌癌作为对照。结果表明:嗜铬颗粒蛋白A免疫组化染色19/20例阳性,免疫电镜能够比较特异地标记神经分泌颗粒,具有确诊意义;神经特异性烯醇化酶染色20/20例阳性,非神经内分泌癌3/6例阳性,免疫电镜下无特异性分布,适宜作为诊断的筛选指标;S-100蛋白和5-HT亦可作为诊断之参考。
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| 关 键 词： | 肺癌 神经内分泌癌 免疫组化 免疫电镜 |
Study on Neuroendocrine Carcinoma of the Lung by Immunohistochemistry and Immunoelectronmicroscopy |
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| Da Jiping et al Dept of Pathol,General Hospital of Air Force,Bejing.Study on Neuroendocrine Carcinoma of the Lung by Immunohistochemistry and Immunoelectronmicroscopy[J].Chinese Journal of Clinical and Experimental Pathology,1993(Z1). |
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| Authors: | Da Jiping Dept of Pathol General Hospital of Air Force Bejing |
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| Institution: | Da Jiping et al Dept of Pathol,General Hospital of Air Force,Bejing 100036 |
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| Abstract: | Twenty cases with neuroendocrinecarcinoma of the lung(NECL)were studied byimmunohistochemistry and immunoelectron-microscopy.Six cases with non-NECL used ascontrol.Immunohistiochemical staining forChromogranin A(CgA)showed 19 postitivity in20 cases,Immunoelectronmicroscopy specifical-ly demonstrated the same phenomenen.CgAstaining would play important role in pathologi-cal diagnosis.All 20 cases with NECL showedpositive staining for NSE and 3 in the 6 caseswith non-NECL were also positive.So we con-sidered that NSE only could be used as a scan-ning marker. |
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| Keywords: | lung carcinoma neuroendocrine carcinoma immunohistochemistry immunoelectronmicroscropy |
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