多发性骨髓瘤肾损害临床表现及相关因素分析

目的：观察多发性骨髓瘤（MM）肾损害的临床表现及相关因素。方法回顾性分析我院65例MM患者临床资料，应用Cockcroft-Gault方程评估肾功能，按Ccr小于60mL/min/1.73 m2与大等于60mL/min/1.73m2将患者分为A、B两组，进行两组间临床资料的比较。结果 A组β2微球蛋白、尿酸、血钙、尿轻链蛋白、贫血发生率均高于B组，（P〈0.05）。β2微球蛋白、尿酸、血钙、尿轻链蛋白、血红蛋白水平对肾功能均有明显影响。结论 MM肾损害有一定的临床特点，肾损害与β2微球蛋白、尿酸、血钙、尿轻链蛋白、贫血关系密切。

A clinical Features and relevant factors analysis of renal impairment in Multiple myeloma

Objective To investigate the clinical features of renal impairment in patients with multiple myeloma（MM） and analyze the relevant factors. Methods Retrospective analysis of clinical data of 65 patients with MM . Renal function was evaluated by Cockcroft-Gault equations. According to the Ccr,Patients were divided into two groups：group A： Ccr〈60mL/ min/（ 1.73m2）; group B：Ccr≥60mL/ min/（1.73m2）. Then comparison of the clinical data between them.Results Compared with group B, group A beta-2 microglobulin, uric acid, blood calcium, urinary protein light chain, the incidence of anemia all higher （P〈0.05）. beta-2 microglob-ulin, uric acid, blood calcium, urinary protein light chain, hemoglobin levels all adverse renalfunction obviously. Conclusion Renal damage in MM has certain clinical features. IT have close relationship to beta 2 microglobulin, uric acid, blood calcium, urinary protein light chain, anemia.