五羟色胺转运体启动子区多态性与焦虑症的关联研究

目的探讨焦虑症与五羟色胺转运体基因启动子区（5-HTTLPR）多态性的相关性。方法运用聚合酶链反应技术检测88例焦虑症患者（包括42名广泛性焦虑障碍和38名惊恐障碍）和87名健康对照者5-HTFLPR的分布频率。结果对照组检测到1例EL／EL基因型，未见其他文献报道。患者组启动子区多态性的超长（EL）等位基因频率为1．1％．对照组为4．6％，两组间差异有显著性（P〈0．05）。两组间各基因型分布差异无显著性；广泛性焦虑障碍组EL／S、L／L、L／S、S／S基因型频率分别为2.4％，9．8％，39．0％和48．8％，惊恐障碍组分别为2.7％，8．1％，43．2％和45．9％，两组间差异无显著性，各等位基因频率比较差异亦无显著性。结论5-HTTLPR的EL等位基闲可能是焦虑症的保护基因之一，焦虑症两种亚型间5-HTFLPR多态性差异无显著性。

Association study of anxiety disorder and serotonin transporter promoter gene polymorphic region

ObjectiveTo explore the association between anxiety disorder and polymorphism of serotonin transporter promoter gene(5-HTTLPR).MethodsUsing a polymerase chain reaction-based technique, 5-HTTLPR genotypes were determined in 88 patients with anxiety disorder and 87 health control subjects, the allelic and genotypic distributions in two groups were compared.ResultsThe frequencies of serotonin transporter(5-HTT) allele extra long(EL) were significantly lower in patients with anxiety disorder than that in controls(1.1% vs (4.6)%, P=0.02). There were no differences on the distributions of 5-HTT genetype between patients and controls. The allelic and genotypic distributions have no significant differences between generalized anxiety disorder and panic disorder.ConclusionThe allele EL may be a protecting factor for anxiety disorder and there were no significant difference on the polymorphism of 5-HTTLPR between the two subtypes of anxiety disorder.