B-Lymphoid and myeloid lineages biphenotypic acute leukemia with t(8;21)(q22;q22) |
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Authors: | Guangsheng He Depei Wu Aining Sun Yongquan Xue Zhengming Jin Huiying Qiu Xiaowen Tang Miao Miao Zhengzheng Fu Xiao Ma Xiuli Wang Zixin Chen Changgeng Ruan |
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Institution: | (1) Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People’s Republic of China |
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Abstract: | By analyzing the characteristics of morphology, immune phenotype, chromosome karyotype and clinical manifestations of six
cases of B-lymphoid and myeloid lineages biphenotypic acute leukemia (BAL) with t(8;21)(q22;q22), a new subgroup of BAL was
reported. Bone marrow eosinophilia (more than 5%) and pseudo-Chediak abnormalities were not found. Auer rods were also not
identified in four of six cases. Immunophenotype revealed B-lymphoid and myeloid lineages positive, together with frequent
and high expression of CD34 and CD33, and weak expression of HLA-DR. In addition to t(8;21) chromosomal translocation, deletion
of Y chromosome and complex chromosome abnormalities were also found. Chemotherapy for myeloid and lymphoid leukemia simultaneously
produced good response in the patients. BAL with t(8; 21)(q22; q22) might be a new subgroup of BAL, and it was suggested that
the leukemia clone with t(8;21)(q22;q22) might have originated from an early phase of hematopoiesis, and AML1/ETO fusion gene might be related to differentiation of B lymphocyte. |
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Keywords: | Leukemia Biphenotypic Acute t(8 21)(q22 q22) AML1/ETO |
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