奥扎格雷钠注射液对急性脑梗死患者MMP-9水平的影响

目的 观察奥扎格雷钠注射液对急性脑梗死患者的临床疗效及对血清MMP-9水平的影响.方法 65例急性脑梗死患者随机分成奥扎格雷钠组(31例)和常规治疗组(34例),两组均给予常规治疗,奥扎格雷钠组加用奥扎格雷钠注射液80mg,每日2次静滴,疗程14d.采用ELISA法测定两组患者血清MMP-9的水平.结果 奥扎格雷钠组的总有效率明显高于常规治疗组(P＜0.05).两组患者治疗后MMP-9水平均明显下降,奥扎格雷钠组降低更明显(P＜0.05). 结论 奥扎格雷钠注射液可能通过下调血清MMP-9的表达发挥脑保护的作用从而提高对急性脑梗死患者治疗的疗效.

Effect of ozagrel injection on MMP-9 in patients with acute cerebral infarction.

Objective To observe the clinical effects of ozagrel on on acute cerebral infarction patients and the matrix metalloproteinase-9 （MMP-9）level. Methods The 65 patients with acute cerebral infarction were randomly divided into sodium ozagrel group and conventional treatment group consiting 31 and 34 cses ,repeetively.Both of two groups accepted conventional treatment and sodium ozagrel group was added to those in sodium ozagrel group at dose of 80mg in 250ml physiological saline by static drop,2 times daily for 14 days as a course. Enzymelinked immunosorbent Assay was used to detect the levels of serum MMP-9 in both group. Results The total effective rate of sodium ozagrel group was significantly higher than conventional treatment group（P〈0.05）. The MMP-9 levels in two groups decreased,while the sodium ozagrel group was significantly decreased （P〈0.05）. Conclusions Sodium ozagrel might has the neuroptective and therapeutic effect by dowrrregulating the expression of serum MMP-9 level.